In 2006, Fisher starred as Becca, a Manhattan party host, in the relationship drama London co-starring Jessica Biel, Chris Evans, and Jason Statham. She played the role of Katie in the romantic comedy Wedding Daze with Jason Biggs. In 2007, she appeared in The Lookout, a thriller film co-starring Joseph Gordon-Levitt and Matthew Goode, and Hot Rod, opposite Andy Samberg. She was scheduled to appear in The Simpsons Movie, although her appearance was cut from the final version. In 2008, she starred in the critically acclaimed romantic comedy film Definitely, Maybe, with Ryan Reynolds, Elizabeth Banks, Rachel Weisz, and Abigail Breslin,and had a voice role in Horton Hears a Who! Fisher has also co-written a script entitled Groupies with Amy Poehler, as well as another project entitled The Cookie Queen. She starred in the movie adaptation of the book Confessions of a Shopaholic, which opened on 13 February 2009. In the film, Fisher played a college graduate who works as a financial journalist in New York City to support her shopping addiction. Confessions of a Shopaholic suffered critically but eventually opened at #4 grossing $15,054,000 on its opening weekend. Fisher received her third Teen Choice Award nomination.
Fisher has spoken out against the lack of opportunities for comediennes in Hollywood. In 2010, she starred in the black comedy Burke and Hare. Fisher then voiced the role of Beans in Rango, a computer-animated Western film released in March 2011. In the movie, Johnny Depp and her Definitely, Maybe co-star Abigail Breslin also provide voice-over roles.
