Her other film appearances and roles include the 2003 comedy Dummy, the 2004 drama Down to the Bone, the 2006 crime thriller The Departed, the 2007 horror Joshua, and the 2008 drama The Boy in the Striped Pyjamas. Farmiga gained critical acclaim following her work in the 2009 comedy-drama Up in the Air, for which she was nominated for an Academy Award, a BAFTA Award, a Golden Globe Award, and a Screen Guild Actors Award. She also starred as Kate Coleman in "Orphan" in 2009.
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On June 25, 2010, she was inducted into the Academy of Motion Picture Arts and Sciences. Farmiga with Keanu Reeves started filming the surrealist romantic comedy film Henry's Crime in December 2009, with filming set to wrap in early 2010. The film was screened at the 2010 Toronto International Film Festival on September 14. Farmiga appears in the techno-thriller Source Code, which is set to be released on April 15, 2011 by Summit Entertainment. Her role in the film is Carol Goodwin. She also has her directorial debut in the 2011 film Higher Ground.