Lisicki has won three WTA singles tournaments in her career (one in 2009 and two in 2011) and one doubles tournament (in 2011). She reached the semifinals of the 2011 Wimbledon Championships and also reached the quarterfinals of the 2009 Wimbledon Championships. She achieved her career high rank of World No. 17 on 12 September 2011. After struggling with injuries in 2010, Lisicki rebounded in 2011 and re-entered the top 100 of the world rankings. She is only the second player in Wimbledon history to make it to the semifinals while entering the tournament as a wildcard.
Her parents emigrated to West Germany from Poland in 1979; her father, Dr. Richard Lisicki, is of German and Polish descent, and her mother, Elisabeth, of Polish. Lisicki currently lives in Bradenton, Florida.
Seeded 22nd at the 2011 US Open, she easily advanced to the second round with a straight-sets win over Alona Bondarenko. She was scheduled to play Venus Williams in the second round, but Williams withdrew before it started due to her recent diagnosis of Sjögren's syndrome. Lisicki dispatched Irina Falconi 6–0, 6–1 to advance to the fourth round for the first time, before ultimately being defeated by second seed Vera Zvonareva 2–6, 3–6.
