Jovovich began modeling at age 11, when photographer Gene Lemuel discovered her and convinced Herb Ritts to shoot her for the cover of Lei magazine. Richard Avedon featured her in Revlon's "Most Unforgettable Women in the World" advertisements, and she continued her career with other campaigns for L'Oréal cosmetics, Banana Republic, Christian Dior, Donna Karan, and Versace. In 1988, she had her first professional acting role in the television film The Night Train to Kathmandu, and later that year, she appeared in her first feature film, Two Moon Junction. Following more small television appearances such as the "Fair Exchange" (1989) and a 1989 role as a French girl (she was 14 at the time) on a Married with Children episode and film roles, she gained notoriety with the romance film Return to the Blue Lagoon (1991). She appeared in 1993's Dazed and Confused alongside Ben Affleck and Matthew McConaughey. Jovovich then acted alongside Bruce Willis in the science fiction film The Fifth Element (1997), and later played the title role in The Messenger: The Story of Joan of Arc (1999). In 2002, she starred in the video game adaptation Resident Evil, which spawned three sequels: Resident Evil: Apocalypse (2004), Resident Evil: Extinction (2007) and Resident Evil: Afterlife (2010).
In addition to her modeling and acting career, Jovovich released a music album, The Divine Comedy in 1994. She continues to release demos for other songs on her official website and contributes to film soundtracks; Jovovich has yet to release another album. In 2003, she and model Carmen Hawk created the clothing line Jovovich-Hawk, which ceased operations in early 2008. In its third season prior to its demise, the pieces could be found at Fred Segal in Los Angeles, Harvey Nichols, and over 50 stores around the world. Jovovich also has her own production company, Creature Entertainment.
In 2002, Jovovich starred in the horror/action film Resident Evil, released in the United States on March 15, 2002. Based on the CAPCOM video game series of the same name, she portrayed Alice, the film's heroine who fights a legion of zombies created by the evil Umbrella Corporation. Jovovich had accepted the role of Alice because she and her brother had been fans of the video game franchise, saying, "It was exciting for me just watching him play, I could sit for 5 hours and we would sit all day and play this game." Jovovich had performed all the stunts required in the film, except for a scene that would involve her jumping to a cement platform, which her management deemed too dangerous, and had trained in karate, kickboxing, and combat-training. The film was commercially successful, grossing $17 million on its opening weekend, and gaining $40 million domestically and $102 million worldwide. Later, she portrayed the manipulative gang wife Erin in No Good Deed (2002), Nadine in the romantic comedy You Stupid Man (2002), punk rocker Fangora ("Fanny") in Dummy (2003), and provided a guest voice on the television series King of the Hill. The role of Fangora in Dummy, allowed Jovovich to act in film with Oscar-winning Adrien Brody, who was a friend prior to filming. Jovovich found it easy to identify with this role because she felt Fangora, as opposed to previous characters, possessed similar qualities to the actress' own life.
In 2004, Jovovich reprised the role of Alice in the sequel to Resident Evil, Resident Evil: Apocalypse. The role required her to do fight training for three hours a day, in addition to the three months prior to filming in which she had "gun training, martial arts, everything". Apocalypse received even more negative reactions from the critics than the first film, but it was a even more commercial success, ranking number one at the box office unlike the first film. Following the release of the film, Jovovich was unhappy with the critical results and director Alexander Witt's effort. She noted during an interview that year that her large action films take care of the commercial part of her career, while she acts in "independent little films that never come out" to appease her artistic side, and "It's a good balance". The following year, she was featured in Gore Vidal's faux trailer remake of Caligula, as Drusilla. In 2006, Jovovich's film, the science fiction/action thriller Ultraviolet, was released on March 3. She played the title role of Violet Song jat Shariff, a role that also involved heavily choreographed fight sequences and Gun Kata, a fictional martial art combining statistical analysis and gunplay. It was not screened for critics, but when reviewed, it was critically panned, grossing $31 million worldwide. That year, Jovovich also starred in .45, as Kat, the revenge driven girlfriend of an illegal gun and drug dealer with English actor and DJ Angus Macfadyen.
